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GSH concentration is instead measured by either of two methods: by analysis of GS-NEM conjugates by HPLC in the same sample that is used to measure GSSG or, alternatively, by analysis of GSH by spectrophotometry (GSH recycling method) on one additional sample aliquot that has not been derivatized with NEM
Other approaches that healthcare professionals may take are described below
Cryotherapy There is also some evidence that cryotherapy the application of cold gloves/boots or continuous-flow cooling systemsto decrease nerve damage during chemotherapy may be effective for prevention of CIPN
If you are considering a high-dose protocol, consulting with a healthcare professional is recommended
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