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The optimization of mitochondrial function and structure is consistent with the common mechanism by which GLP-1RAs improve sarcopenia by increasing mitochondrial area and quantity, and optimizing their morphology [36]

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin

Secondary prevention of CVD (adults) To reduce the risk of major adverse CV events (CV death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established CV disease and either obesity or overweight WEIGHT LOSS IN ADULTS RCT STEP 1 Study - Wegovy vs Placebo for Weight Loss in Adults Without Diabetes, NEJM (2021) [PubMed abstract] The STEP 1 study enrolled 1961 overweight or obese adults without diabetes Main inclusion criteria Age 18 years 1 failed attempt at dieting BMI 30 or 27 with one weight-related condition (e.g