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As the majority of patients with type 2 diabetes are overweight or obese this offers a potential advantage over older, established therapies, and DPP-4 inhibitors are being used in clinical practice as second-line therapy in addition to metformin in overweight and obese patients who fail to reach glycemic targets with metformin monotherapy
doi: 10.1152/physrev.00018.2001 72 DrgeW.BreitkreutzR
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