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Lillig CH, Berndt C
In the study, participants with a responsive genetic score had an 82% increase in the likelihood of acheiving weight loss with a GLP-1 medication.[ref] Another study showed that GLP1 receptor variants are associated with greater weight loss on GLP-1 RA drugs.[ref] Common genetic variants in the GLP1R (GLP-1 receptor) gene impact weight and type 2 diabetes risk
Constipationconsider fluids + fiber
This led to large dedicated weight-loss trials in people with overweight or obesity, including people without diabetes
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