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[Abstract] BR-CHAC1-OE and MR-CHAC1-OE cells were treated with DMSO, AZD4547 (2.5 M) with or without GSH (10 mM) and NAC (5 mM) for 72 h, and cell viability was measured by the CCK-8 assay

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The antibiotic nitrofurantoin (NFT) was identified to stimulate de novo synthesis of glutathione in the human hepatoma cell line, HepG2, and in primary human hepatocytes

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The absorption gap: Oral glutathione must survive stomach acid, intestinal enzymes, and first-pass liver metabolism before entering systemic circulation

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