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Type 2 diabetes is a complex metabolic disorder often requiring combination therapy for optimal glycaemic control

Germande O, Baudrimont M, Beaufils F, Freund-Michel V, Ducret T, Quignard JF et al (2022) NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption

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Instead of targeting only GLP-1 receptors, Tirzepatide activates both: GLP-1 receptors GIP receptors This dual-action approach may provide additional metabolic benefits and, in some studies, has demonstrated greater average weight loss than Semaglutide