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Reactions that spread beyond the immediate injection area, involve significant swelling, or are accompanied by fever or systemic symptoms require medical evaluation
Spiking experiments into the plasma fraction prior to extraction showed that enzymes catalyzing the conversion of NADH to NAD+ are localized in plasma, while those affecting NAD + , NADP + and NADPH are associated with the cellular fraction (Supplementary Table 1, Sample Type 4)
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