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Chinda et al (22) reported that the administration of vildagliptin (another DPP-4 inhibitor) prior to LAD occlusion in a rat ischemia/reperfusion model, modulated cardiac electrophysiology by normalizing the shortening of the effective refractory period, decreasing the occurrence of premature ventricular contractions and increasing the ventricular fibrillation threshold during the ischemic period
Constant, non-pulsatile GH rise (as occurs with synthetic GH use) can lead to receptor desensitization, where target tissues become less responsive to growth hormone over time
Nutritional deficiencies can develop quickly if appetite is suppressed, and food intake drops
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