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Ferritin and iron can promote the development of NAFLD through oxidative stress [24]

The youngest patients, Gen Z, reported the highest rates (61%), followed by millennials (34%), Gen X (21%), and baby boomers (19%)

VIP is critical for preserving ENS function: VIP-deficient mice exhibit attenuated jejunal motility (Lelievre et al., 2007), and downregulated VIP expression correlates with severe constipation, indicating attenuated VIP signaling as a common pathological feature in dysmotility ( Escherichia coli (but not Lactobacillus ) restores its levels, suggesting specific microbial metabolites modulate VIP synthesis ( 4.3.3 Nitric oxide Nitric oxide (NO), a key inhibitory neurotransmitter, is synthesized by NOS via the catalysis of L-arginine