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Glucagon receptor activation increases hepatic glucose output and energy expenditure, but it also influences bile acid production and gastrointestinal motility
For instance, two obese individuals taking the same dose may experience dramatically different weight loss and fat loss
It's important to understand that the people who are going on GLP-1s are likelier to be lifelong weight cyclers, are likelier to be the people who when there is failure or problems, they're likelier to blame themselves for those errors, those problems, those failures
Figure 2 Table 3 Practical framework for biomarker development
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