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Nrf2 upregulates the expression of dozens of cytoprotective enzymes, including GCL itself, creating a compensatory response to oxidative stress

Two separate human clinical trials have investigated this compound: Ulcerative Colitis Trial Clinical investigation of this compound in patients with ulcerative colitis examined the compounds GI-protective properties properties that are consistent with its gastric origin and documented activity on intestinal permeability barriers in animal models

LC-MS confirms identity by measuring the molecular mass and comparing it to the theoretical value (403404 g/mol for the parent complex, 462 g/mol for the acetate salt)

It also supports collagen production, improves fibroblast activity (important for wound healing), and helps regulate inflammatory cytokines