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A significant concern is that the most common adverse effects of GLP-1 agonistsnausea, vomiting, diarrhea, and abdominal painoverlap substantially with Crohn's disease symptoms
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Given the high risk of sarcopenic obesity and metabolic adaptations after significant weight loss, future clinical trials are needed to assess optimal dietary patterns, protein dosing and timing, protein supplementation, and resistance training interventions to better promote muscle health outcomes during weight loss
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