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If menstrual irregularities cause significant distress or interfere with quality of life, healthcare providers may consider several approaches
Managing these side effects might involve lowering the dose, increasing the dose more gradually, splitting the dose, taking the medication with food, or combining spironolactone with a combined oral contraceptive to stabilize menstrual cycles and reduce breakthrough bleeding
A total of 13 studies included in the SLR exclusively enrolled people with T2DM 2331 or a proportion of participants with T2DM
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