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Immunohistochemical staining showed higher expression of p16 in keloids than that in normal skin ( p = 0.01

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Eur J Cancer 1996

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Some experts caution that surgical intervention for large CMN with surgical procedures such as excision and grafting, laser ablation, dermabrasion, and chemical peels may not only prevent the detection of melanoma within the treated areas but may in fact increase the risk of malignant degeneration by altering the biological behavior of residual melanocytes

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Avoid submerging the injection site in pools or hot tubs for 24 hours to minimize infection risk from the small skin puncture

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