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Sasaki H, Sato H, Kuriyama-Matsumura K, Sato K, Maebara K, Wang H, et al

MSC treatment resulted in hepatocyte proliferation and neovascularization through hepatic growth mediators WNT2 and HGF secreted by LSEC in the VEGF-A/Flk1/Id1 signaling pathway [99, 101]

Although these experiments had no effects on tumor viability, the concept was later picked up by Wilhelm Brnings 178 , 179 who combined maximally tolerable doses of insulin treatment with a KD into a de-glycation method (Entzuckerungsmethode) for the treatment of head and neck cancer patients in his clinic