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Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1

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However, researchers working with 10 mg vials often target 8-10 mg as their maintenance dose, falling within the range that produced 22-24% weight loss in the trial

This approach allows adaptation to the compound while minimizing adverse effects during adjustment periods