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These studies suggest a dynamic involvement of Irs2 which may be differentially affected across drug (stimulant versus sedative) and knock-out models in the presence or absence of these drugs

J Transl Med 17:55 Tsai SY, Lin CL, Shih SC, Hsu CW, Leong KH, Kuo CF, Lio CF, Chen YT, Hung YJ, Shi L (2018) Increased risk of chronic fatigue syndrome following burn injuries

For many patients, what matters is therefore not simply buying the medication, but receiving a proper medical evaluation that takes into account comorbidities, previous treatments, and tolerability

NTS1 has also been implicated in sleep and psychiatric disorders which often co-occur with AUD and can increase the proclivity for relapse