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When these proteins are abnormally expressed, the overload cytosolic free ferrous iron leads to intracellular ROS accumulation via the Fenton reaction, which eventually promotes lipid peroxides formation and ferroptosis occurrence (186)
To do this, we used a previous program to study whole-body acetaminophen metabolism [10]
Ajani JA, Faust J, Yao J, Komaki R, Stevens C, Swisher S , Putnam JB, Vaporciyan A, Smythe R, Walsh G, Rice D, Roth J
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