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Handling and preparation should follow institutional SOPs and appropriate laboratory safety controls

Anything that disrupts parietal cells, intrinsic factor, or the intestinal lining interrupts this chain which is the mechanism behind most of the deficiency causes covered later in this article

Its ultra-long half-life supports once-monthly administration while achieving clinically meaningful weight reduction, potentially improving long-term adherence

The dose of the double-blind study medication was increased by 2.5 mg every 4 weeks as tolerated until a dose of 15.0 mg per week of tirzepatide or matching placebo could be achieved after 20 weeks, which was maintained until the end of the trial