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Introduction Dipeptidyl peptidase-4 (DPP-4), which is also referred to as adenosine deaminase complexing protein 2 (ADCP2), cluster of differentiation 26 (CD26), or adenosine deaminase binding protein (ADBP), is an important protease that is widely expressed on the surface of human cells
Lee YH, Lee CJ, Lee HS, Choe EY, Lee BW, Ahn CW, Cha BS, Lee HC, Balkau B, Kang ES
Within participants with pre-existing SUDs, initiation of a GLP-1 receptor agonist was associated with reduced risk of SUD related emergency department visits (hazard ratio 0.69 (95% CI 0.61 to 0.78), NRD 8.92 (95% CI 11.59 to 6.25)), SUD related hospital admission (0.74 (0.65 to 0.85), NRD 6.23 (8.73 to 3.74)), and SUD related mortality (0.50 (0.32 to 0.79), NRD 1.52 (2.32 to 0.72)), and associated with reduced risk of the composite endpoint of the three outcomes (0.71 (0.65 to 0.79), NRD 11.79 (14.98 to 8.60)) (fig 6 and supplementary table S11)
The proposed mechanism for the benefits of GLP-1 RAs in HS appears to involve both weight reduction and direct effects on the immune system [33]
