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However, the reduced risks of hospitalized hypoglycemia and all-cause mortality associated with the use of a GLP-1RA versus insulin may lead to a favorable cost-utility profile for using a GLP-1RA

Tirzepatide should be used with caution in patients with a history of pancreatitis, as GLP-1 receptor agonists have been associated with acute pancreatitis in postmarketing reports

Domperidone shows effectiveness as a selective dopamine D2 antagonist that does not cross the bloodbrain barrier [65]

GLP-1RA appeared to exert neuroprotective effects primarily by regulating microglia, which were the most significant immune cells in the central nervous system (41)