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Microsomes (1 mg/ml) in sodium phosphate buffer, pH 7.4 were supplemented with NADPH (10 mM) and NFT (5 mM)

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From a global epidemiologic perspective, it is associated with increased morbidity and mortality, healthcare costs, absenteeism, and presenteeism ( Evidence-based guidelines provide recommendations to healthcare professionals (HCP) for intense lifestyle interventions (ILI) with the aim of weight reduction and mitigation of cardiovascular risk ( Metabolic bariatric surgery (MBS) stands out as the most effective treatment for severe obesity, demonstrating significant and sustained weight loss while also improving various obesity-related health complications ( The development of safe and effective pharmacological agents for obesity has encountered significant challenges, marked by the emergence and subsequent decline of many medications due to adverse side effects, such as cardiovascular risk ( ) was approved in 2012