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This ROS-induced injury can lead to apoptosis, disruptions in ion regulation, and mitochondrial dysfunction, further exacerbating the inflammatory response and tissue damage
1e, f) suggested placement of polar and non-polar substituents in multiple locations, including those that were relatively remote, we intentionally limited the modifications to those in proximity or to the putative chimera molecule itself to maximize the potential for further improvements during structure-activity relationship (SAR) studies
Disrupted NMDA signaling has also been implicated in a wide range of neuropsychiatric disorders other than ASD, including ID, schizophrenia, Alzheimers disease, and other mood disorders [66], suggesting different roles of NMDARs in synaptic plasticity and excitotoxicity [67, 68]
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