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At low concentrations, scLCDV-VILP also induced cell proliferation, but the curve was shifted one-order of magnitude to the right, peaking at 10 nM and then decreasing to basal levels with further increases in ligand, suggesting a self-inhibitory effect

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As a transcriptional suppressor, Hes1 in the retina inhibits the differentiation of specific cell types and leads to excessive gliosis, increased inflammatory cytokine release, and ECM imbalance

The trial had dual primary endpoints defined as change from baseline in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) and change in body weight