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Free Cu2+ is toxic (Fenton reactions, hydroxyl radicals), but the GHK-Cu complex is stable, diffusible and delivers copper in a targeted manner to copper-dependent metalloenzymes: lysyl oxidase (collagen/elastin crosslinking), Cu/Zn superoxide dismutase (SOD1, antioxidant defence), tyrosinase (controlled melanogenesis), dopamine-beta-hydroxylase

Each takes a different approach to the same fundamental problem, and understanding their distinct mechanisms helps you determine which one, or which combination, fits your situation

[PMID: 38862786] PubMed record related to this compound for laboratory literature review

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