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It has recently been shown that GLP-1R neurons in the dorsomedial hypothalamic nucleus regulate pancreatic activity by affecting the dorsal motor nucleus of the vagus, specifically lowering blood glucose levels by increasing insulin release (Huang et al., 2022)
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Rather than targeting appetite or insulin signaling, this peptide is a modified fragment of human growth hormone, specifically amino acids 176 through 191, that directly stimulates fat metabolism without the broader effects of full growth hormone therapy
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