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Severely impaired ceruloplasmin synthesis and biliary function create conditions where even small exogenous copper loads may accumulate

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Rather than broadly applying this therapy if it is approved, we suggest careful patient selection and monitoring by clinicians pending further studies

Naijil G, Anju TR, Jayanarayanan S et al (2015) Curcumin pretreatment mediates antidiabetogenesis via functional regulation of adrenergic receptor subtypes in the pancreas of multiple low-dose streptozotocin-induced diabetic rats