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However, GLP-1 inhibitors have a long half-life approximately five weeks

The anthranoid laxatives pass through the gastrointestinal tract unabsorbed until they reach the large intestine, where they are changed into their active forms

Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics

DOI: 10.1038/s41392-024-01931-z, Zhu, Q., Chen, Z., Paul, P