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Bao et al (60) found downregulation of the ferroptosis regulator GPX4 in both Fpnfl/fl/NEXcre (NEX-Cre mice were mated with Fpn-floxed (Fpnfl/fl) mice to generate conditional Fpnfl/fl/NEXcre mice.) and APPswe/PS1dE9 (Carrying genetically modified mice with AD-related mutations: a chimeric mouse/human APP with the Swedish mutation and human PSEN1 lacking exon 9) mouse models compared with controls

This undergoes a series of changes in the liver and kidneys to become its active form, known as calcitriol (or vitamin D3)

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Oral supplementation is convenient, but absorption can vary due to breakdown in the digestive tract, says Chaudhry