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Conversely, in a recent randomized, double-blind, placebo-controlled study involving twenty healthy volunteers, a once-weekly injection of a GLP-1R agonist, dulaglutide, for three weeks did not influence HPA axis activity, showing no significant effects on circadian rhythms of blood or salivary cortisol secretion, and the level of this hormone also was not changed after the dexamethasone suppression test in comparison with the placebo-receiving group [78]

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Thalidomide a drug, perhaps known more for its controversial 1950s history as a sedative for pregnant women with morning sickness, which was withdrawn after it was found to lead to severe skeletal birth defects was repurposed and approved by the FDA about 60 years later for use in combination with dexamethasone in patients with newly diagnosed multiple myeloma

This transformation promotes the escape and release of NADs encapsulated in LNPs