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Simultaneously, it downregulates genes associated with inflammation (IL-6, TNF-alpha), oxidative damage, fibrosis (TGF-beta in some contexts), and tissue destruction (certain metalloproteinases)
SELECT showed direct cardiovascular benefit of semaglutide in patients with established cardiovascular disease and overweight or obesity
Clinical results: The SURMOUNT-1 trial, published in the New England Journal of Medicine, showed tirzepatide produced average weight loss of 20.9 percent at the 15 mg dose
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