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The incretin effect is a cornerstone of endocrinology

Im sticking to it. Obstacles to adjunctive therapy approval for type 1 diabetes Dutta, who has led Breakthrough T1Ds research on adjunctive therapies for the past 15 years, believes there are several reasons why adjunctive therapies have not made headway with type 1 diabetes

In pancreatic -cells, the stimulation of GLP-1R leads to a reduction in ROS production, safeguarding against apoptosis induced by oxidative stress and promoting insulin secretion

The lysophosphatidylcholine-HIF-1 axis enhances apolipoprotein E sialylation and promotes electronegative LDL accumulation, iScience, 29 , 6, (116167), (2026)