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While vitamin B12 supports cellular energy metabolism, supplementing B12 in a patient who is not deficient does not increase metabolic rate or cause fat loss

Recent evidence from the STEP-HFpEF and STEP-HFpEF-DM trials provides the first robust data supporting the efficacy of GLP-1 RAs, specifically semaglutide, in improving the quality of life in obese patients with HFpEF

This is legally distinct from therapeutic supply under the TGA's regulatory framework

A doctor may ask about fatigue, muscle weakness, fasting intolerance, diet, medications, family history, and any past episodes of low blood sugar or unexplained illness