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GLP-1 is a 30-amino acid peptide secreted by intestinal L-cells in response to food intake, released from pro-glucagon by the action of pro-hormone convertase, which processes preproglucagon, the precursor of several glucagon-related peptides
GLP-1 therapy is generally not recommended during breastfeeding due to theoretical concerns about infant exposure and caloric restriction during lactation
Taken together, the addition of other metabolic hormones to GLP-1R agonism results in superior effects on glucose and energy homeostasis
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