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Alternative Therapies in Health and Medicine , 31(5), 2024
TXNRDs catalyze the reduction of a wide range of substrates, including thioredoxin and protein disulfide isomerase (PDI) (see Figure 2b )
Its unique mechanism allows it to complement GLP-1 signaling without overlapping receptor pathways (Enebo et al.)
Together, these results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of a chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage
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