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Unexpected adverse events should be reported to the FDA MedWatch program
Because the mechanism targets cytokine signaling cascades that amplify through second-messenger systems
Those who eat less meat, have autoimmune or thyroid conditions are also more likely to experience anemia caused by vitamin B12 deficiency
Some other exposures (eg, use of proton pump inhibitors, H2-receptor blocking agents, or metformin) might raise suspicion that this was a significant or sufficient cause, but by itself is not sufficient proof that such an exposure actually caused a vitamin B insufficiency
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