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H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)
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GLP-1s work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity in ways that compound over months of consistent use
These are unstable molecules that can cause oxidative stress, which is essentially the biological equivalent of rust on a machine
