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Semax is formally an analog of the ACTH(4-10) fragment, the active core Met-Glu-His-Phe capped with a stabilizing Pro-Gly-Pro tail that keeps it from being chewed up too fast, and it is stripped of the parent hormones effects on the adrenal glands, so it acts on the brain without the stress-hormone baggage
But the point is that there's a lot more going on in the brain that's been talked about for a lot longer than simply this accumulation of beta-amyloid
Inflammation is associated with increased glutamate, whereas the antioxidant glutathione may protect against inflammation-induced oxidative stress
