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It is presumed that some of the benefits are related to weight, but a prespecified analysis of the SELECT (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity) trial demonstrated that waist circumference reduction accounted for only 33% of the MACE effect, suggesting that the cardioprotective effects of semaglutide extend beyond its impact on adiposity
Retrieved January 19, 2024
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Continuation criteria vary by medication: for Wegovy, evaluate at 20 weeks with a target of 5% weight loss
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