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Dysesthesia: A New Signal for Retatrutide The TRIUMPH-4 Phase 3 trial revealed an unexpected finding: dysesthesia (abnormal touch sensations where normal sensations feel unusual or painful) in 20.9% of participants on 12 mg and 8.8% on 9 mg, compared to 0.7% on placebo (BioSpace, Dec 2025)

The PlexusDx Precision Peptide Genetic Test maps 14 metabolic pathways and 49 peptides, including variants in FTO and MC4R genes that affect appetite regulation and weight loss response