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Safer alternatives include optimising tirzepatide monotherapy with appropriate dose titration, structured NHS lifestyle programmes, licensed GLP-1 receptor agonists like semaglutide (Wegovy), or referral for bariatric surgery assessment
Once steady state is achieved, each new weekly injection adds fresh medication to existing levels, maintaining a therapeutic window throughout the seven-day period
Hachua M, Kosowski M, Ryl S, Basiak M, Okopie B
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