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Semaglutides SUSTAIN-6 trial demonstrated a significant reduction in major adverse cardiovascular events in adults with type 2 diabetes, along with improvements in body weight and HbA1c (NCBI Bookshelf)
The SURPASS-3 MRI substudy, published in The Lancet Diabetes and Endocrinology, provided a more nuanced picture
Rather than acting on a single organ, GLP-1 communicates with the brain, pancreas, stomach, and liver, creating a coordinated metabolic response
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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