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Spermatozoa are vulnerable to ROS because their plasma membrane and cytoplasm contain large amounts of polyunsaturated fatty acids (Alvarez & Storey, 1995), resulting in a decrease in sperm motility, presumably by a rapid loss of intracellular ATP, causing axonemal damage (de Lamirande & Gagnon, 1992), a decrease in sperm viability and an increase in mid-piece morphology defects, with deleterious effects on sperm capacitation and acrosome reaction

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Jul 2008;56(7):1292-8

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Experimental work using c-Fos immunoreactivity as a marker demonstrated that PT-141 can activate neurons in specific hypothalamic regions

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