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It downregulates the expression of pro-inflammatory factors: GSDMD, NLRP3, IL-1, IL-18 and Caspase-1 in vivo , and blocks renal inflammation driven by NF-B and renal fibrosis mediated by TGF-/Smad3 through blocking the Smad7 degradation pathway mediated by Smurf2, preventing apoptosis of renal tubular epithelial cells through regulating the TXNIP-NLRP3-GDMD axis in vitro
White mulberry leaf has a long history of use in traditional Chinese medicine for preventing and treating diabetes (Mudra 2007)
Additionally, established procedures help support reliable batch-to-batch performance and standardized research material preparation
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