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doi: 10.1016/j.amjmed.2009.11.019 54 RosenstockJKlaffLJSchwartzSNorthrupJHolcombeJHWilhelmKet al

Karagiannis T et al (2017): Canagliflozin in the treatment of type 2 diabetes: an evidence-based review of its place in therapy

In SURMOUNT-1, participants on 15mg achieved an average weight loss of 22.5%, approximately 52 pounds or 24 kilograms over 72 weeks

Many teams also build in a washout period at the end of a study before any follow-up dosing phase, giving the GH axis time to return to baseline and reducing the risk of carryover effects confounding a subsequent phase