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Phosphorylation of the DSGIS motif in NRF2 mediated by glycogen synthase kinase-3 beta (GSK-3) promotes the binding of -TrCP to NRF2 which is therefore marked for ubiquitination and then degraded by the proteasome [145, 149,150,151]
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PubMed laboratory research record [PMID: 10206412] PubMed record related to this compound for laboratory literature review
doi: 10.1038/s41418-022-01046-4
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