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At the epigenetic level, decreasing NAD + /NADH ratio with age inhibits SIRT1/3 activity and impairs PGC-1-mediated mitochondrial biosynthesis and antioxidant gene expression [292, 293]
In 2025, Im still skeptical of these claims, he says
References Aebi H (1984) [13] Catalase in vitro
At present, clinical use in adults living with obesity focuses on supporting weight reduction and metabolic health as part of medically supervised care
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