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Those with inadvertent exposure in the first trimester did not manifest any increase in fetal kidney or cardiac abnormalities compared to matched controls, according to a retrospective cohort study of 3652 women with T2DM

Its mostly available as an injectable (subcutaneous)

These subcutaneous injections are significantly less painful than injections into muscles such as flu shots

Similar results were obtained in experiments with sorted MCF-7-ER36 + cells in nude mice (Figure 3H and Supplementary information, Figure S4G), whereas MCF7/mock cells failed to form lung metastasis foci, even with estrogen or tamoxifen treatment