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Questo meccanismo insulinotropico glucosio-dipendente spiega la bassa incidenza di eventi ipoglicemici associati alla terapia con GLP-1RA, sia quando sono utilizzati da soli che in duplice o triplice terapia con metformina, sulfoniluree, pioglitazone o insulina
It is a prescription medicine and the examination before prescribing is a full medical safety assessment, not a formality
GLP-1 receptors are abundant in brain regions controlling appetite, reward, and metabolic regulation, including the hypothalamus, brainstem, and nucleus tractus solitarius
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