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it might even worsen some side effects

Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders

Additionally Asp2 carboxylate is also coordinated near N-terminal Cu(I) ion, which can mediate formation of the in-between state 23

Although a role for mechanical forces inducing a change in conformation of the Nesprin-2 cytoplasmic domain that makes SRs more accessible for binding to PDZ cannot be formally excluded (Grum et al, 1999), our results are more consistent with nuclear tension activating RhoA by promoting accumulation of Nesprin-2 and associated PDZ RhoGEF at the base of chromatin bridges for two main reasons: First, targeting RhoA to the cytoplasmic region of Nesprin-2 by inserting the DH/PH domain of PDZ in mini-Nesprin-2 protein CH* did not promote actin patch formation in the absence of Nesprin-2 accumulation